What did I look here if no-thing? Meaning making is also about getting lost in discoveries.īut, here I'll return to the thing 'in place': announcement of the - not culmination - but perhaps ' compilement' of acts done with materials presented in Alkovi by Mikko Kuorinki under the title S/T during the timeframe of mid February 2022 until mid May 2022. You have made them with varying level of intention perhaps, but seeking to solidify the experience they are there.Īn artwork and an exhibition as such provide these solidifications and moments for trying to grasp something because escape from these solidifications also becomes tangible. You can say that everything in essence is a constant movement, but just like returning from a holiday or a trip 'outside' (a walk perhaps) - there has been points of entry and exit. The impossibility of denying the desire for this moment becomes clear when you find yourself faced with the notion of 'termination' - an ending to your process, project or "journey" so to speak. That is the lure of a 'finished work' or an exhibition as well. Found in situations when a statement is to be made to satisfy both the audience and the one looking for a resolution (for a while at least). Proclaiming that something is done, a deed is conducted, is found in the practices seeking closure, even if it might only be some form of a rest (and) stop.
#Iina kurkinen full
But more so something that is not in full view, nor could be but temporarily seen, in a moment in sight.Īs exhibition builds up so that the 'finished' piece is presented - or in a case when trying to evade that (that the thing in view is constantly being build or reshuffled, becoming temporally performative) - the element of announcement becomes a site of tension and decision. Something that has a hint of sinister in it. "Flashing" maybe in correlating word in English. That is perhaps best translated and described as an act when someone very briefly shows him or herself (or some object) to others/viewer(s). 'Näyttely' which is the Finnish word for 'exhibition' has for me the connotation of 'vilauttelu'. This is what the current 'exhibition' has subtly but directly been, placing "things" on view. This opens for me an avenue into thinking about the things placed inside it as samples of material thinking - thinking in materials as ways of exposure. That in Finnish is 'näyteikkuna' and could literally also be translated as 'a sample window'. Alkovi is an art space set in a display window. HOWEVER I'M ONLY HUMAN AND I MAY MISS SOMETHING" PLEASE VIEW THE PHOTOS CLOSELY, I DO MY BEST TO DESCRIBE THE CONDITION, NOTING ANY FLAWS. NOTE, FLAWS, DUST, DIRT WILL BE MAGNIFIED BY THE CAMERA. HAS SOME AGEING, WEAR, SMALL MINOR NICK MANUFACTURE FLAW POSSIBLE HERE OR THERE. RARE CRUDE VTG/ANTIQUE PORCELAIN BIRDCAGE SMALL GRAVEL SEED TREAT FEEDER "GOOD CONDITION FOR IT'S AGE. Ingredients and acts were listed to the website: Mikko Kuorinki's exhibition S/T was build and changed during its presentation. Mikko Kuoringin näyttely S/T rakentui ja muuntui esilläolonsa ajan, ainesosat sekä teot luetteloitiin verkkosivuille: Toukokuuta 2022 / 12th of February to 12th of May, 2022* ERK1/2, SAPK/JNK, and p38, and suggest that targeted modulation of the ceramide signaling pathway may offer a novel therapeutic approach for inhibiting collagenolytic activity, e.g. These results show that triggering the ceramide signaling pathway activates MMP-1 gene expression via three distinct MAPK pathways, i.e. In addition, ceramide-dependent induction of MMP-1 expression is potently prevented by PD 98059, a selective inhibitor of MEK1 activation, and by specific p38 inhibitor SB 203580.
#Iina kurkinen Activator
Activation of MMP-1 promoter by C 2-ceramide is also effectively inhibited by kinase-deficient forms of ERK1/2 kinase (MEK1/2) activator Raf-1, ERK1 and ERK2, SAPK/JNK activator SEK1, or SAPKβ.
Stimulation of MMP-1 promoter activity by C 2-ceramide is dependent on the presence of a functional AP-1 cis-element and is entirely inhibited by overexpression of MAPK inhibitor, dual specificity phosphatase CL100 (MAPK phosphatase-1). C 2-ceramide activates three distinct mitogen-activated protein kinases (MAPKs) in dermal fibroblasts, i.e.extracellular signal-regulated kinase 1/2 (ERK1/2), stress-activated protein kinase/Jun N-terminal-kinase (SAPK/JNK), and p38.
Here, we show that triggering the ceramide pathway by sphingomyelinase or C 2- and C 6-ceramide enhances collagenase-1 (matrix metalloproteinase-1 MMP-1) gene expression by fibroblasts. Inflammatory cytokines tumor necrosis factor-α and interleukin-1 trigger the ceramide signaling pathway, initiated by neutral sphingomyelinase-elicited hydrolysis of cell membrane phospholipid sphingomyelin to ceramide, a new lipid second messenger.
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